Could an increase in airway smooth muscle shortening velocity cause airway hyperresponsiveness?
نویسندگان
چکیده
منابع مشابه
Could an increase in airway smooth muscle shortening velocity cause airway hyperresponsiveness?
Airway hyperresponsiveness (AHR) is a characteristic feature of asthma. It has been proposed that an increase in the shortening velocity of airway smooth muscle (ASM) could contribute to AHR. To address this possibility, we tested whether an increase in the isotonic shortening velocity of ASM is associated with an increase in the rate and total amount of shortening when ASM is subjected to an o...
متن کاملAccumulating Evidence for Increased Velocity of Airway Smooth Muscle Shortening in Asthmatic Airway Hyperresponsiveness
It remains unclear whether airway smooth muscle (ASM) mechanics is altered in asthma. While efforts have originally focussed on contractile force, some evidence points to an increased velocity of shortening. A greater rate of airway renarrowing after a deep inspiration has been reported in asthmatics compared to controls, which could result from a shortening velocity increase. In addition, we h...
متن کاملPoint:Counterpoint: Alterations in airway smooth muscle phenotype do/do not cause airway hyperresponsiveness in asthma POINT: ALTERATIONS IN AIRWAY SMOOTH MUSCLE PHENOTYPE DO CAUSE AIRWAY HYPERRESPONSIVENESS IN ASTHMA
Airway hyperresponsiveness and obstruction are cardinal features of asthma. Compelling evidence now suggests that the key features of asthma in part are due to intrinsic differences in airway smooth muscle (ASM) function. Inflammatory mediators alter ASM phenotype, which directly modulates ASM hyperresponsiveness and promotes airway remodeling that further contributes to amplified airway obstru...
متن کاملLast Word on Point: Alterations in airway smooth muscle phenotype do cause airway hyperresponsiveness in asthma.
TO THE EDITOR: We greatly appreciate the readers’ interest and response (see Ref. 2) to the Point:Counterpoint (4, 9) article. We wish to respond to comments focused on whether nature vs. nurture modulates the airway smooth muscle (ASM) phenotype that manifests as airway hyperresponsiveness (AHR). The nature vs. nurture argument was not our main point, rather it was the issue of whether ASM is ...
متن کاملThe smooth muscle and airway hyperresponsiveness.
Airway hyperresponsiveness, excessive airway narrowing caused by stimuli that normally elicit limited or no response, is one of the cardinal features of asthma. The length-dependence of smooth muscle contractility has been recognized for decades, and it forms an essential foundation for many aspects of the physiological regulation of airway contractility in vivo. This review summarizes the stru...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2011
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00228.2010